Maternal Thyroid Function in Early Pregnancy and Neuropsychological Performance of the Child at 5 Years of Age
Andersen, SL; Andersen, S; Liew, Z; Vestergaard, P; Olsen, J
HERO ID
5035111
Reference Type
Journal Article
Year
2018
Language
English
PMID
| HERO ID | 5035111 |
|---|---|
| In Press | No |
| Year | 2018 |
| Title | Maternal Thyroid Function in Early Pregnancy and Neuropsychological Performance of the Child at 5 Years of Age |
| Authors | Andersen, SL; Andersen, S; Liew, Z; Vestergaard, P; Olsen, J |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 103 |
| Issue | 2 |
| Page Numbers | 660-670 |
| Abstract | <strong>Context: </strong>Abnormal maternal thyroid function in pregnancy may impair fetal brain development, but more evidence is needed to refine and corroborate the hypothesis.<br /><br /><strong>Objective: </strong>To estimate the association between maternal thyroid function in early pregnancy and neuropsychological performance of the child at 5 years of age.<br /><br /><strong>Design: </strong>Follow-up study.<br /><br /><strong>Participants: </strong>A cohort of 1153 women and their children sampled from the Danish National Birth Cohort. Maternal thyroid-stimulating hormone (TSH) and free thyroxine (fT4) were measured in stored biobank sera from early pregnancy.<br /><br /><strong>Main outcomes measures: </strong>Child neuropsychological test results (Wechsler Intelligence Scale/Test of Everyday Attention), test of motor function (Movement Assessment Battery), and results of parent and teacher reports (Behavior Rating Inventory of Executive Function/Strengths and Difficulties Questionnaire).<br /><br /><strong>Results: </strong>Altogether 145 children (12.6%) were born to mothers with abnormal thyroid function in the early pregnancy. High maternal TSH and low fT4 were associated with lower child verbal intelligence quotient (adjusted mean difference TSH ≥ 10 mIU/L vs 0.1 to 2.49 mIU/L, -8.9 [95% confidence interval (CI), -15 to -2.4]; fT4 < 10 pmol/l vs 12.0 to 18.99 pmol/l, -13 [95% CI, -19 to -7.3]). Abnormal maternal thyroid function was also associated with adverse motor function and teacher-reported problems of executive function and behavior, and these associations were dominated by exposure to maternal hypothyroxinemia.<br /><br /><strong>Conclusions: </strong>Maternal thyroid hormone abnormalities were associated with adverse neuropsychological function of the child at 5 years of age. For intelligence, marked hypothyroidism was important, whereas for motor function and executive and behavior problems, maternal hypothyroxinemia was predominant. |
| Doi | 10.1210/jc.2017-02171 |
| Pmid | 29220528 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |