Metal-induced developmental toxicity in mammals: A review
Domingo, JL
HERO ID
50704
Reference Type
Journal Article
Subtype
Review
Year
1994
Language
English
PMID
| HERO ID | 50704 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 1994 |
| Title | Metal-induced developmental toxicity in mammals: A review |
| Authors | Domingo, JL |
| Journal | Journal of Toxicology and Environmental Health |
| Volume | 42 |
| Issue | 2 |
| Page Numbers | 123-141 |
| Abstract | It is well established that certain metals are toxic to embryonic and fetal tissues and can induce teratogenicity in mammals. The main objective of this paper has been to summarize the toxic effects that excesses of certain metals may cause on mammalian development. The reviewed elements have been divided into four groups: (a) metals of greatest toxicological significance (arsenic, cadmium, lead, mercury, and uranium) that are wide-spread in the human environment, (b) essential trace metals (chromium, cobalt, manganese, selenium, and zinc), (c) other metals with evident biological interest (nickel and vanadium), and (d) metals of pharmacological interest (aluminum, gallium, and lithium). A summary of the therapeutic use of chelating agents in the prevention of metal-induced developmental toxicity has also been included. meso-2,3-Dimercaptosuccinic acid (DMSA) and sodium 2,3-dimercaptopropane-1-sulfonate (DMPS) have been reported to be effective in alleviating arsenic- and mercury-induced teratogenesis, whereas sodium 4,5-dihydroxybenzene-1,3-disulfonate (Tiron) would protect against vanadium- and uranium-induced developmental toxicity. |
| Doi | 10.1080/15287399409531868 |
| Pmid | 8207750 |
| Wosid | WOS:A1994NT04600001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | J. Toxicol. Environ. Health 42: 123-141.|WOS:A1994NT04600001 |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>DCN-219993</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Developmental disorders</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Laboratory animals</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Toxic effects</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Reproductive hazards</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Teratogens</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Heavy metal poisoning</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Arsenic compounds</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Cadmium poisoning</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Lead poisoning</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Mercury poisoning</kw> |
| Is Qa | No |
| Relationship(s) |
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