Exposure to per-fluoroalkyl and polyfluoroalkyl substances leads to immunotoxicity: Epidemiological and toxicological evidence
Dewitt, JC; Blossom, SJ; Schaider, LA
HERO ID
5080663
Reference Type
Journal Article
Subtype
Review
Year
2019
Language
English
PMID
| HERO ID | 5080663 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2019 |
| Title | Exposure to per-fluoroalkyl and polyfluoroalkyl substances leads to immunotoxicity: Epidemiological and toxicological evidence |
| Authors | Dewitt, JC; Blossom, SJ; Schaider, LA |
| Journal | Journal of Exposure Science & Environmental Epidemiology |
| Volume | 29 |
| Issue | 2 |
| Page Numbers | 148-156 |
| Abstract | In this perspective, we evaluate key and emerging epidemiological and toxicological data concerning immunotoxicity of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) and seek to reconcile conflicting conclusions from two reviews published in 2016. We summarize ways that immunosuppression and immunoenhancement are defined and explain how specific outcomes are used to evaluate immunotoxicity in humans and experimental animals. We observe that different approaches to defining immunotoxicological outcomes, particularly those that do not produce clinical disease, may lead to different conclusions from epidemiological and toxicological studies. The fundamental point that we make is that aspects of epidemiological studies considered as limitations can be minimized when data from toxicological studies support epidemiological findings. Taken together, we find that results of epidemiological studies, supported by findings from toxicological studies, provide strong evidence that humans exposed to PFOA and PFOS are at risk for immunosuppression. |
| Doi | 10.1038/s41370-018-0097-y |
| Pmid | 30482935 |
| Wosid | WOS:000459048700003 |
| Url | https://www.proquest.com/docview/2183202463?accountid=171501&bdid=35863&_bd=viUjFmK%2Brt53i%2BrjqZf1GNHfY%2FQ%3D |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | emerging contaminants; perfluorinated chemicals; population-based studies |
| Is Peer Review | Yes |
| Relationship(s) |
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