Impact of environmental pollutants on the male: Effects on germ cell differentiation
Veeramachaneni, DNR
HERO ID
531427
Reference Type
Journal Article
Year
2008
Language
English
PMID
| HERO ID | 531427 |
|---|---|
| In Press | No |
| Year | 2008 |
| Title | Impact of environmental pollutants on the male: Effects on germ cell differentiation |
| Authors | Veeramachaneni, DNR |
| Journal | Animal Reproduction Science |
| Volume | 105 |
| Issue | 1-2 |
| Page Numbers | 144-157 |
| Abstract | A variety of so-called innocuous chemicals can have insidious and long lasting effects on the developing male reproductive system. Developmental exposures of male rabbits to common industrial contaminants in drinking water (a mixture of arsenic, chromium, lead, benzene, chloroform, phenol, and trichloroethylene); alkyl phenols (e.g. octylphenol); water disinfection by-products (e.g. dibromoacetic acid); anti-androgenic pesticides (e.g. pp'-DDT and vinclozolin); and plasticizers (e.g. dibutyl phthalate) produce testicular dysgenesis. The lesions include testicular carcinoma in situ, also called intratubular germ cell neoplasia - the precursor lesion of germ cell tumors in men, and acrosomal dysgenesis - characterized by sharing of a dysplastic acrosome by two or more spermatids resulting in characteristic sperm acrosomal-nuclear malformations. Certain manifestations of testicular dysgenesis arch across environmental agents, and sequelae of intentional developmental exposures of rabbits duplicate what has been encountered in deer, horses, and humans for which the etiology is uncertain. (C) 2007 Elsevier B.V. All rights reserved. |
| Doi | 10.1016/j.anireprosci.2007.11.020 |
| Pmid | 18155861 |
| Wosid | WOS:000254725800013 |
| Url | https://www.proquest.com/scholarly-journals/impact-environmental-pollutants-on-male-effects/docview/70359533/se-2?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | pesticides; phthalates; chemical pollutants; water disinfection; by-products; testicular dysgenesis; carcinoma in situ; acrosomal dysgenesis |
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