Long-term suppression of GABAergic activity by neonatal seizures in rat somatosensory cortex
Isaeva, E; Isaev, D; Khazipov, R; Holmes, GL
| HERO ID | 5381568 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | Long-term suppression of GABAergic activity by neonatal seizures in rat somatosensory cortex |
| Authors | Isaeva, E; Isaev, D; Khazipov, R; Holmes, GL |
| Journal | Epilepsy Research |
| Volume | 87 |
| Issue | 2-3 |
| Page Numbers | 286-289 |
| Abstract | Here we studied the long-term effects of neonatal seizures on inhibitory synaptic transmission in somatosensory cortex. We found that recurrent flurothyl-induced seizures result in a marked reduction in amplitude of spontaneous inhibitory postsynaptic currents (IPSCs) and increases of miniature IPSCs interevent intervals. These results indicate that decreasing the inhibitory synaptic strength following neonatal seizures in neocortical neurons is not due to a postsynaptic mechanism. |
| Doi | 10.1016/j.eplepsyres.2009.09.011 |
| Pmid | 19828295 |
| Wosid | WOS:000273019500025 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Early seizures; GABA; Somatosensory cortex |