Effects of trichloroethylene, 1,1,1-trichloroethane and carbon tetrachloride on plasma lipoproteins of rats
Honma, T
HERO ID
5382
Reference Type
Journal Article
Year
1990
Language
English
PMID
| HERO ID | 5382 |
|---|---|
| In Press | No |
| Year | 1990 |
| Title | Effects of trichloroethylene, 1,1,1-trichloroethane and carbon tetrachloride on plasma lipoproteins of rats |
| Authors | Honma, T |
| Journal | Industrial Health |
| Volume | 28 |
| Issue | 4 |
| Page Numbers | 159-174 |
| Abstract | The effects of trichloroethylene (79016) and 1,1,1-trichloroethane (71556) on plasma lipoproteins of rats were studied and related to the changes in liver and plasma transaminase activities. The effects were compared with effects of carbon-tetrachloride (56235). Male Fischer-344-rats were used in the study. The solvents were dissolved in 1 milliliter of olive-oil/kilogram of body weight and injected intraperitoneally at 19 hours before sacrifice. On the administration of carbon-tetrachloride at 30 to 1000mg/kg, very low density lipoproteins (VLDL) and high density lipoproteins (HDL) were dose dependently reduced, but the reduction in low density lipoproteins (LDL) was not dose dependent. Injection of trichloroethylene at 30 to 30mg/kg decreased the lipid contents of VLDL and LDL fractions. Trichloroethylene at 1000mg/kg increased VLDL and LDL. The HDL was decreased with increasing doses of trichloroethylene at 30 to 1000mg/kg. VLDL and LDL were increased by treatment with 100 or 300mg/kg 1,1,1-trichloroethane. HDL levels rose at 100 but fell at 1000mg/kg. Liver to body weight ratios were raised with increasing doses of the three compounds. Plasma GOT and GPT activities rose at much higher doses of solvents than dose levels which produce the changes in lipoproteins and the increases in liver weights. |
| Doi | 10.2486/indhealth.28.159 |
| Pmid | 2283324 |
| Wosid | WOS:A1990ET48400002 |
| Url | https://search.proquest.com/docview/80248632?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Ind. Health 28: 159-174. |
| Is Public | Yes |
| Language Text | English |
| Keyword | TRICHLOROETHYLENE; 1,1,1-TRICHLOROETHANE; CARBON TETRACHLORIDE; PLASMA; LIPOPROTEINS; VLDL; LDL; HDL; HEPATOTOXICITY; GOT; GPT; RAT |
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