Inhibition of the rate of GABA synthesis in regions of rat brain following a convulsion
Green, AR; Metz, A; Minchin, MC; Vincent, ND
| HERO ID | 5383175 |
|---|---|
| In Press | No |
| Year | 1987 |
| Title | Inhibition of the rate of GABA synthesis in regions of rat brain following a convulsion |
| Authors | Green, AR; Metz, A; Minchin, MC; Vincent, ND |
| Journal | British Journal of Pharmacology |
| Volume | 92 |
| Issue | 1 |
| Page Numbers | 5-11 |
| Abstract | 1 The rate of synthesis of gamma-aminobutyric acid (GABA) in the cortex, hippocampus and striatum of rat brain was assessed by measuring the linear rate of accumulation of GABA following injection of amino-oxyacetic acid (AOAA). 2 Five min after a single electrically induced seizure there was a rise in GABA content in these brain regions and an almost total inhibition of the rate of synthesis. 3 Five min after seizure induced by the inhalant convulsant flurothyl there was no rise in GABA content in these brain regions but a similar marked degree of inhibition of GABA synthesis. 4 Two hours after the convulsion the rate of GABA synthesis had returned to control values in all three brain regions. 5 A single convulsion did not alter the glutamic acid decarboxylase activity in these brain regions either in the absence or presence of added co-factor (pyridoxal phosphate). 6 Evidence for an inhibition of GABA release following a convulsion which may be associated with the inhibition of GABA synthesis is presented in the following paper. |
| Doi | 10.1111/j.1476-5381.1987.tb11288.x |
| Pmid | 3664092 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |