Redirected to reference 3809272
Decarboxylase inhibitors affect convulsion thresholds to hexafluorodiethyl ether
Truitt, EB; Ebersberger, EM
| HERO ID | 5383308 |
|---|---|
| In Press | No |
| Year | 1962 |
| Title | Decarboxylase inhibitors affect convulsion thresholds to hexafluorodiethyl ether |
| Authors | Truitt, EB; Ebersberger, EM |
| Journal | Science |
| Volume | 135 |
| Issue | 3498 |
| Page Numbers | 105-106 |
| Abstract | Alpha-methyl dihydroxyphenylalanine (alpha-MeDOPA) and alpha-methyl meta-tyrosine (alpha-MMT) do not lower significantly the convulsion thresholds to hexafluorodiethyl ether in the mouse, whereas reserpine and tetrabenazine produce marked lowering of these thresholds. Other workers have shown that alpha-MeDOPA and alpha-MMT decrease brain norepinephrine concentrations much more than brain 5-hydroxytryptamine concentrations, while reserpine and tetrabenazine decrease the brain level of these two amines in a parallel fashion. Thus, the fact that alpha-MeDOPA and alpha-MMT, even in very large doses, do not lower convulsion thresholds and in some cases raise them suggests that the decline in 5-hydroxytryptamine may be implicated in the lowering of convulsion thresholds produced by reserpine and other, similar agents. |
| Doi | 10.1126/science.135.3498.105 |
| Pmid | 13922689 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |