Effect of long- and short-chain perfluorinated compounds on cultured thyroid cells viability and response to TSH
Croce, L; Coperchini, F; Tonacchera, M; Imbriani, M; Rotondi, M; Chiovato, L
HERO ID
5387182
Reference Type
Journal Article
Year
2019
Language
English
PMID
| HERO ID | 5387182 |
|---|---|
| In Press | No |
| Year | 2019 |
| Title | Effect of long- and short-chain perfluorinated compounds on cultured thyroid cells viability and response to TSH |
| Authors | Croce, L; Coperchini, F; Tonacchera, M; Imbriani, M; Rotondi, M; Chiovato, L |
| Journal | Journal of Endocrinological Investigation |
| Volume | 42 |
| Issue | 11 |
| Page Numbers | 1329-1335 |
| Abstract | <strong>PURPOSE: </strong>Perfluorinated chemicals are widespread pollutants persistent in the environment with links to some major health issues. The two main compounds, perfluoro-octanoic acid (PFOA) and perfluoro-alkyl sulphonate (PFOS), were recently classified as carcinogenetic and thus their use has been restricted. Short-chain PFCs were recently developed as an alternative, but no data regarding the possible endocrine toxicities of these compounds are available. Aim of this study was to investigate whether short-chain PFCs could jeopardize thyroid cell viability and/or interfere with the functional effect TSH.<br /><br /><strong>METHODS: </strong>Fisher rat thyroid line-5 (FRTL-5) was treated with increasing concentrations of PFOA, PFOS, perfluorobutanesulfonic acid (PFBS), perfluorobutanoic acid (PFBA), pentafluoropropionic anhydride (PFPA), perfluoropentanoic acid (PFPeA) to evaluate modifications in cell viability and TSH-stimulated cAMP production.<br /><br /><strong>RESULTS: </strong>Neither long nor short-chain PFCs affected cell viability (apart from PFOS 100 µM), or interfered with cAMP production.<br /><br /><strong>CONCLUSIONS: </strong>The results of the present study demonstrate for the first time that short-chain PFCs have no acute cytotoxic effect on thyroid cells in vitro and that cAMP production is not modulated by any of the tested PFCs. |
| Doi | 10.1007/s40618-019-01062-1 |
| Pmid | 31102255 |
| Wosid | WOS:000491957500008 |
| Url | http://link.springer.com/10.1007/s40618-019-01062-1 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066085066&doi=10.1007%2fs40618-019-01062-1&partnerID=40&md5=8eb30ad8a34462632d9cc9bd68057f06 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Perfluorinated compounds; Thyroid; FRTL-5; Endocrine disruptors; PFOA; PFOS |