Intravenous self-administration of abused solvents and anesthetics in mice
Blokhina, EA; Dravolina, OA; Bespalov, AY; Balster, RL; Zvartau, EE
HERO ID
5387761
Reference Type
Journal Article
Year
2004
Language
English
PMID
| HERO ID | 5387761 |
|---|---|
| In Press | No |
| Year | 2004 |
| Title | Intravenous self-administration of abused solvents and anesthetics in mice |
| Authors | Blokhina, EA; Dravolina, OA; Bespalov, AY; Balster, RL; Zvartau, EE |
| Journal | European Journal of Pharmacology |
| Volume | 485 |
| Issue | 1-3 |
| Page Numbers | 211-218 |
| Abstract | Volatile organic solvents, fuels and anesthetics are subject to abuse. The aim of the present study was to evaluate i.v. self-administration of several of these chemicals in drug- and experiment-naive mice using a commercially available vehicle, intralipid. Two strains of mice (DBA/2 and Swiss) were allowed to self-administer toluene (0.0017-0.17 micromol/infusion), 1,1,1-trichloroethane (0.006-0.19 micromol/infusion), ethanol (0.32-1.6 micromol/infusion), cyclohexane (0.0017-0.052 micromol/infusion), propofol (0.01-0.53 micromol/infusion) and flurothyl (0.00042-0.072 micromol/infusion) or their vehicles during 30-min tests. During the test, each nose-poke of the master mouse resulted in a 1.88-microl i.v. infusion to the master mouse and a yoked control mouse. When the delivery line was loaded with a reinforcing drug solution, the number of nose-pokes of the master mice significantly exceeded that for yoked control mice. In the present experiments, significant differences in rates of nose-poking were observed between mice receiving response-contingent and response-noncontingent deliveries of ethanol and toluene in both strains of mice and of 1,1,1-trichloroethane in Swiss mice. These data suggest that the reinforcing effects of abused inhalants can be studied using i.v. self-administration procedures. |
| Doi | 10.1016/j.ejphar.2003.11.068 |
| Pmid | 14757143 |
| Wosid | WOS:000188712500026 |
| Url | http://www.sciencedirect.com/science/article/pii/S0014299903027390 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | SCOTTSDALE, AZ |
| Conference Name | 63rd Annual Meeting of the College-on-Problems-of-Drug-Dependence |
| Is Public | Yes |
| Language Text | English |
| Keyword | Ethanol; Self-administration; (Mouse) |