Report on carcinogenesis bioassay of 1,2-dichloroethane (EDC)
HERO ID
5436090
Reference Type
Journal Article
Year
1978
Language
English
PMID
| HERO ID | 5436090 |
|---|---|
| In Press | No |
| Year | 1978 |
| Title | Report on carcinogenesis bioassay of 1,2-dichloroethane (EDC) |
| Journal | American Industrial Hygiene Association Journal |
| Volume | 39 |
| Issue | 11 |
| Page Numbers | A26-A30 |
| Abstract | In a carcinogenesis bioassay of the halogenated solvent 1,2-dichloroethane (ethylene dichloride, or EDC), oral administration of the compound produced cancers in rats and mice. In male rats, dosage with EDC caused forestomach cancers, hemangiosarcomas (vascularized cancers) of multiple organs, and subcutaneous fibromas (cancers beneath the skin). Female rats exposed to EDC developed mammary (breast) cancers--in some high-dose animals as early as the 20th week of the study. The chemical also caused breast cancers as well as uterine cancers in female mice, and respiratory tract cancers in both male and female mice. |
| Pmid | 735995 |
| Url | https://search.proquest.com/docview/74209096?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Carcinogens; Ethylene Dichlorides; Hydrocarbons, Chlorinated; Index Medicus; Dose-Response Relationship, Drug; National Institutes of Health (U.S.); Animals; Body Weight -- drug effects; United States; Ethylene Dichlorides -- toxicity; Hydrocarbons, Chlorinated -- toxicity; Ethylene Dichlorides -- administration & dosage |
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