Incorporation of in vitro metabolism data in a physiologically based pharmacokinetic (PBPK) model for chloroprene
HERO ID
5467423
Reference Type
Technical Report
Year
2020
Language
English
| HERO ID | 5467423 |
|---|---|
| Year | 2020 |
| Title | Incorporation of in vitro metabolism data in a physiologically based pharmacokinetic (PBPK) model for chloroprene |
| Authoring Organization | Ramboll |
| Abstract | A physiologically based pharmacokinetic (PBPK) model for chloroprene in the mouse, rat and human has been developed that relies solely on in vitro studies for the estimation of model parameters describing tissue metabolism and partitioning. The PBPK model accurately predicts in vivo pharmacokinetic data from a 6-hr, nose-only chloroprene inhalation study conducted with female B6C3F1 mice, the most sensitive species/gender for lung tumors in the 2-year bioassays conducted with chloroprene. This PBPK model has been developed to support an inhalation cancer risk assessment for chloroprene using in vitro data on the metabolism of chloroprene to reactive epoxides in the lung target tissue of mice and humans. The approach for calculating target tissue (lung) dose metrics was based on the PBPK modeling performed in support of the inhalation cancer risk assessment for methylene chloride and represents the best available science for determining the impact of species differences in metabolism of chloroprene. |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
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