Difference in uptake, elimination, and metabolism in exposure to trichloroethylene, 1,1,1-trichloroethane, and tetrachloroethylene
Monster, AC
HERO ID
58265
Reference Type
Journal Article
Year
1979
Language
English
PMID
| HERO ID | 58265 |
|---|---|
| In Press | No |
| Year | 1979 |
| Title | Difference in uptake, elimination, and metabolism in exposure to trichloroethylene, 1,1,1-trichloroethane, and tetrachloroethylene |
| Authors | Monster, AC |
| Journal | International Archives of Occupational and Environmental Health |
| Volume | 42 |
| Issue | 3-4 |
| Page Numbers | 311-317 |
| Abstract | The relatively high and almost constant absorption/min of trichloroethylene (TRI) is explained by the relatively high partition coefficient between blood and air (lambdab/g = 15) combined with the rapid metabolism (75 %). Tetrachloroethylene (PERC) has about the same lambdab/g as TRI, but the metabolism is insignificant (2 %); therefore, the amount taken up/min decreases in the course of exposure. The lambdab/g (5) for 1,1,1-trichloroethane (MC) is smaller, the metabolism is insignificant (3.5 %), therefore the capacity of the body to absorb MC is relatively small and in consequence the uptake/min decreases fast in the course of exposure. Due to the lower lambdab/g the excretion of MC after exposure is much faster than of PERC. As a result of the metabolism of TRI only a relatively small amount of TRI absorbed is excreted by the lungs after exposure. |
| Doi | 10.1007/BF00377785 |
| Pmid | 422272 |
| Wosid | WOS:A1979GG35600018 |
| Url | https://search.proquest.com/docview/74399369?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Int. Arch. Occup. Environ. Health 42: 311-317. |
| Is Public | Yes |
| Language Text | English |
| Keyword | Environmental Exposure; Hydrocarbons, Chlorinated/metabolism; Tetrachloroethylene/metabolism/urine; Trichloroethanes/metabolism/urine; Trichloroethylene/metabolism/urine; 290YE8AR51; TJ904HH8SN |
| Is Qa | No |