Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by several sulfur-containing compounds
Wattenberg, LW
HERO ID
59696
Reference Type
Journal Article
Year
1974
Language
English
PMID
| HERO ID | 59696 |
|---|---|
| In Press | No |
| Year | 1974 |
| Title | Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by several sulfur-containing compounds |
| Authors | Wattenberg, LW |
| Journal | Journal of the National Cancer Institute |
| Volume | 52 |
| Issue | 5 |
| Page Numbers | 1583-1587 |
| Abstract | HEEP COPYRIGHT: BIOL ABS. Disulfiram, dimethyldithiocarbamate and benzyl thiocyanate, when added to the diet, inhibited 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumor formation and adrenal necrosis in female Spraque-Dawley rats. A single oral administration of disulfiram given 24 hr before the carcinogen similarly inhibited DMBA-induced mammary tumor formation. In the mouse, disulfiram prevented the occurrence of tumors of the forestomach that resulted from benzo(a)pyrene in the diet but did not affect pulmonary adenoma formation in mice given this carcinogen by oral intubation. |
| Doi | 10.1093/jnci/52.5.1583 |
| Pmid | 4831442 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | JNCI J. Natl. Cancer Inst. 52: 1583-1587. |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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