The fate of intratracheally installed benzo(a)pyrene in the isolated perfused rat lung of both control and 20-methylcholanthrene pretreated rats
Vainio, H; Uotila, P; Hartiala, J; Pelkonen, O
HERO ID
59896
Reference Type
Journal Article
Year
1976
Language
English
PMID
| HERO ID | 59896 |
|---|---|
| In Press | No |
| Year | 1976 |
| Title | The fate of intratracheally installed benzo(a)pyrene in the isolated perfused rat lung of both control and 20-methylcholanthrene pretreated rats |
| Authors | Vainio, H; Uotila, P; Hartiala, J; Pelkonen, O |
| Journal | Research Communications in Molecular Pathology and Pharmacology |
| Volume | 13 |
| Issue | 2 |
| Page Numbers | 259-271 |
| Abstract | The fate of intratracheally installed 3H-benzo(a)pyrene in the isolated perfused rat lung of both control and 20-methylcholanthrene pretreated rats and in perfusion fluid was studied. The covalent binding of benzo(a)pyrene metabolites in the lung tissue itself was greatly enhanced by 20-methylcholanthrene pretreatment of rats. Similarly, the appearance of unchanged 3H-benzo(a)pyrene in the perfusion fluid of 20-methylcholanthrene-lung was decreased as compared to control lung perfusion. This was accompanied with the increase of water-soluble metabolites of benzo(a)-pyrene in the perfusion fluid of 20-methylcholanthrene-lung. When analyzing the metabolite profile of benzo(a)-pyrene in the lungs, especially the phenols (7-fold) and 9,10-diols (5-fold) were found to be increased. |
| Pmid | 1257613 |
| Wosid | WOS:A1976BG75700010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Is Peer Review | Yes |
| Relationship(s) |
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