Convenient Temporary Methyl Imidate Protection of N-Acetylglucosamine and Glycosylation at O-4
Cheng, A; Hendel, JL; Colangelo, K; Bonin, M; Auzanneau, FI
| HERO ID | 603059 |
|---|---|
| In Press | No |
| Year | 2008 |
| Title | Convenient Temporary Methyl Imidate Protection of N-Acetylglucosamine and Glycosylation at O-4 |
| Authors | Cheng, A; Hendel, JL; Colangelo, K; Bonin, M; Auzanneau, FI |
| Journal | Journal of Organic Chemistry |
| Volume | 73 |
| Issue | 19 |
| Page Numbers | 7574-7579 |
| Abstract | The article discusses the methods for the preparation of antigens containing N-acetylglucosamine residues glycosylated at O-4. It discusses the synthesis of alkyl imidate protected glucosamine acceptors at position 4 and various protecting groups at O-3. It infers that alkyl imidate products were readily converted to their corresponding N-acetyl derivatives under mild conditions in all cases. Glycosylation reaction via alkyl imidate protected acceptor intermediates is also presented. |
| Doi | 10.1021/jo801117y |
| Pmid | 18767802 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | GLYCOSYLATION; ANTIGENS; GLUCOSAMINE; ALKYLATION; CHEMICAL reactions; ACETYLATION |
| Is Qa | No |