Mechanism of testicular atrophy induced by di-n-butyl phthalate in rats. Part 1
Fukuoka, M; Tanimoto, T; Zhou, Y; Kawasaki, N; Tanaka, A; Ikemoto, I; Machida, T
HERO ID
61559
Reference Type
Journal Article
Year
1989
Language
English
PMID
| HERO ID | 61559 |
|---|---|
| In Press | No |
| Year | 1989 |
| Title | Mechanism of testicular atrophy induced by di-n-butyl phthalate in rats. Part 1 |
| Authors | Fukuoka, M; Tanimoto, T; Zhou, Y; Kawasaki, N; Tanaka, A; Ikemoto, I; Machida, T |
| Journal | Journal of Applied Toxicology |
| Volume | 9 |
| Issue | 4 |
| Page Numbers | 277-283 |
| Abstract | Repeated oral doses of di-n-butyl phthalate (DBP) to male rats caused a decrease in testicular fructose and glucose and a sloughing of the germ cells on the first day of treatment. On day 2, more severe sloughing was seen and was accompanied by decreases in testicular iron and zinc levels and increases in the level of inositol and cholesterols. The sloughing was followed by atrophy, accompanied by dissociation of the germ cells from the Sertoli cells and reduction of triglycerides, cholesterols and phospholipids containing choline and ethanolamine residues in the testis. |
| Doi | 10.1002/jat.2550090413 |
| Pmid | 2506265 |
| Wosid | WOS:A1989AH97300012 |
| Url | http://onlinelibrary.wiley.com/doi/10.1002/jat.2550090413/abstract |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Phthalic Acids; Dibutyl Phthalate; 2286E5R2KE; L-Iditol 2-Dehydrogenase; EC 1.1.1.14; Aldehyde Reductase; EC 1.1.1.21; Index Medicus; Magnetic Resonance Spectroscopy; Aldehyde Reductase -- metabolism; Chromatography, Gas; Rats, Inbred Strains; Seminiferous Tubules -- pathology; Atrophy; Animals; L-Iditol 2-Dehydrogenase -- metabolism; Time Factors; Seminiferous Tubules -- drug effects; Organ Size -- drug effects; Testis -- pathology; Testis -- enzymology; Dibutyl Phthalate -- toxicity; Phthalic Acids -- toxicity; Testis -- metabolism |
| Is Peer Review | Yes |
| Relationship(s) |