Mutagenicity testing with TA97 and TA102 of 30 DNA-damaging compounds, negative with other Salmonella strains
De Flora, S; Camoirano, A; Zanacchi, P; Bennicelli, C
HERO ID
626223
Reference Type
Journal Article
Year
1984
Language
English
PMID
| HERO ID | 626223 |
|---|---|
| In Press | No |
| Year | 1984 |
| Title | Mutagenicity testing with TA97 and TA102 of 30 DNA-damaging compounds, negative with other Salmonella strains |
| Authors | De Flora, S; Camoirano, A; Zanacchi, P; Bennicelli, C |
| Journal | Mutation Research |
| Volume | 134 |
| Issue | 2-3 |
| Page Numbers | 159-165 |
| Abstract | In a comparative study on 135 compounds of various chemical classes, 30 agents inducing direct nonreparable DNA damage in repair-deficient E. coli failed in reverting strains TA1535, TA1537, TA1538, TA98 and TA100 of S. typhimurium (De Flora et al., 1984b). These compounds were re-assayed in the Ames test using strains TA97 and TA102. A dose-dependent mutagenic response was detected with aminoantipyrine and p-rosaniline in TA97 and with streptomycin and formaldehyde in TA102. p-Rosaniline was the only mutagen requiring metabolic activation. 5 compounds, i.e. o-aminophenol in TA97 and methanol, ethanol, cadmium chloride and cadmium sulfate in TA102, induced a reproducible increase in revertants over controls, but this was less than 2-fold. The remaining 21 chemicals--including amino compounds, aliphatics, aromatics, heterocycles, hydrazine derivatives and inorganics--confirmed their inactivity in the Ames test. Overall data for 135 compounds, comparing the Ames test (7 strains) and the DNA-repair test (3 strains), are re-assessed on the basis of these findings. |
| Doi | 10.1016/0165-1110(84)90009-5 |
| Pmid | 6390191 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>DCN-147572</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Medical research</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Toxicopathology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>In vitro studies</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Bioassays</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Mutagens</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Chromosome damage</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Cell damage</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Cytotoxic effects</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Bioactivation</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biological effects</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Quantitative analysis</kw> |
| Relationship(s) |
|