Weak promotion of C3H/10T1/2 cell transformation by repeated treatments with formaldehyde
Frazelle, JH; Abernethy, DJ; Boreiko, CJ
HERO ID
626346
Reference Type
Journal Article
Year
1983
Language
English
PMID
| HERO ID | 626346 |
|---|---|
| In Press | No |
| Year | 1983 |
| Title | Weak promotion of C3H/10T1/2 cell transformation by repeated treatments with formaldehyde |
| Authors | Frazelle, JH; Abernethy, DJ; Boreiko, CJ |
| Journal | Cancer Research |
| Volume | 43 |
| Issue | 7 |
| Page Numbers | 3236-3239 |
| Abstract | C3H/10T 1/2 cells were treated with N-methyl-N'-nitro-N-nitrosoguanidine and then repeatedly exposed to formaldehyde (0.1 to 2.0 micrograms/ml). Exposure of N-methyl-N'-nitro-N-nitrosoguanidine-initiated cultures to formaldehyde concentrations of 0.5 or 1.0 micrograms/ml in a variety of treatment regimens resulted in focus formation in up to 9% of the treated dishes. Transformed foci were observed in 2% or less of the cultures treated with N-methyl-N'-nitro-N-nitrosoguanidine or formaldehyde alone. Formaldehyde thus appears to be only a weak tumor promoter for C3H/10T 1/2 cell transformation. |
| Pmid | 6850633 |
| Wosid | WOS:A1983QV62900040 |
| Url | http://<Go to ISI>://WOS:A1983QV62900040 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>DCN-141229</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Industrial chemicals</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Cell biology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Cell damage</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Molecular biology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biological effects</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Cellular function</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Cancer</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Carcinogenesis</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Carcinogenicity</kw> |
| Is Peer Review | Yes |