Biomedicine. Asthmatics breathe easier when it's SNO-ing
Gerard, C
HERO ID
626376
Reference Type
Journal Article
Subtype
Comment
Year
2005
Language
English
PMID
| HERO ID | 626376 |
|---|---|
| Material Type | Comment |
| In Press | No |
| Year | 2005 |
| Title | Biomedicine. Asthmatics breathe easier when it's SNO-ing |
| Authors | Gerard, C |
| Journal | Science |
| Volume | 308 |
| Issue | 5728 |
| Page Numbers | 1560-1561 |
| Abstract | Asthma is now recognized as an epidemic in the developed world, focusing attention on possible therapies. Although much has been learned over the last two decades about the pathogenesis of asthma, this complex disease resists magic-bullet therapies. In part, this resistance may be caused by the large number of genes that interact with underlying physiology and environmental factors to trigger disease. The chronic inflammation of the asthmatic lung results from an allergic reaction marked by elevated immunoglobulin E, mast cells and eosinophils, and cytokines such as interleukin-5 and interleukin-13. This chronic inflammation causes bouts of acute airway constriction. Eventually, asthmatic lungs show permanent changes: increased mucus cell mass, hypertrophy of the smooth muscle cells, and deposition of collagen just below the lining of the epithelial surface. |
| Doi | 10.1126/science.1114163 |
| Pmid | 15947161 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |