Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells
Grafstrom, RC; Fornace, AJ, Jr; Autrup, H; Lechner, JF; Harris, CC
HERO ID
626437
Reference Type
Journal Article
Year
1983
Language
English
PMID
| HERO ID | 626437 |
|---|---|
| In Press | No |
| Year | 1983 |
| Title | Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells |
| Authors | Grafstrom, RC; Fornace, AJ, Jr; Autrup, H; Lechner, JF; Harris, CC |
| Journal | Science |
| Volume | 220 |
| Issue | 4593 |
| Page Numbers | 216-218 |
| Abstract | Cultured bronchial epithelial and fibroblastic cells from humans were used to study DNA damage and toxicity caused by formaldehyde. Formaldehyde caused the formation of cross-links between DNA and proteins, caused single-strand breaks in DNA, and inhibited the resealing of single-strand breaks produced by ionizing radiation. Formaldehyde also inhibited the unscheduled DNA synthesis that occurs after exposure of cells to ultraviolet irradiation or to benzo[a]pyrene diolexpoxide but at doses substantially higher than those required to inhibit the resealing of x-ray-induced single-strand breaks. Therefore, formaldehyde could exert its mutagenic and carcinogenic effects by both damaging DNA and inhibiting DNA repair. |
| Doi | 10.1126/science.6828890 |
| Pmid | 6828890 |
| Wosid | WOS:A1983QH95800041 |
| Url | http://www.sciencemag.org/cgi/doi/10.1126/science.6828890 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Is Peer Review | Yes |