Sample size requirements for association studies of gene-gene interaction
Gauderman, WJ
| HERO ID | 626945 |
|---|---|
| In Press | No |
| Year | 2002 |
| Title | Sample size requirements for association studies of gene-gene interaction |
| Authors | Gauderman, WJ |
| Journal | American Journal of Epidemiology |
| Volume | 155 |
| Issue | 5 |
| Page Numbers | 478-484 |
| Abstract | In the study of complex diseases, it may be important to test hypotheses related to gene-gene (G x G) interaction. The success of such studies depends critically on obtaining adequate sample sizes. In this paper, the author investigates sample size requirements for studies of G x G interaction, focusing on four study designs: the matched-case-control design, the case-sibling design, the case-parent design, and the case-only design. All four designs provide an estimate of interaction on a multiplicative scale, which is used as a unifying theme in the comparison of sample size requirements. Across a variety of genetic models, the case-only and case-parent designs require fewer sampling units (cases and case-parent trios, respectively) than the case-control (pairs) or case-sibling (pairs) design. For example, the author describes an asthma study of two common recessive genes for which 270 matched case-control pairs would be required to detect a G x G interaction of moderate magnitude with 80% power. By comparison, the same study would require 319 case-sibling pairs but only 146 trios in the case-parent design or 116 cases in the case-only design. A software program that computes sample size for studies of G x G interaction and for studies of gene-environment (G x E) interaction is freely available (http://hydra.usc.edu/gxe). |
| Doi | 10.1093/aje/155.5.478 |
| Pmid | 11867360 |
| Wosid | WOS:000174153800014 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | ssociation; case-control studies; genetics; interaction; research design; sample size |
| Is Qa | No |