Multigenerational effects in deer mice (Peromyscus maniculatus) exposed to hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX)
Smith, JN; Espino, MA; Liu, J; Romero, NA; Cox, SB; Cobb, GP
HERO ID
627839
Reference Type
Journal Article
Year
2009
Language
English
PMID
| HERO ID | 627839 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | Multigenerational effects in deer mice (Peromyscus maniculatus) exposed to hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX) |
| Authors | Smith, JN; Espino, MA; Liu, J; Romero, NA; Cox, SB; Cobb, GP |
| Journal | Chemosphere |
| Volume | 75 |
| Issue | 7 |
| Page Numbers | 910-914 |
| Abstract | Contamination by hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) has been identified at areas of explosive manufacturing, processing, storage, and usage. Anaerobic conversion of RDX to N-nitroso metabolites (hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX), hexahydro-1,3-dinitroso-5-nitro-1,3,5-triazine (DNX), and hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX)) has been demonstrated in the environment and in gastrointestinal tracts of mammals in vivo. Thus, potential exists for exposure to these N-nitroso compounds. While exposed to TNX via drinking water ad libitum, deer mice (Peromyscus maniculatus) were bred in three generations to produce cohorts F1A-D, F2A-B, and F3A. TNX was administered at four exposure levels: control (0 microg L(-1)), 10 microg L(-1), 100 microg L(-1), and 1000 microg L(-1). Endpoints investigated include: offspring production, offspring survival, offspring weight gain, and offspring organ weights. TNX exposure decreased litter size and increased postpartum mortality of offspring at the highest exposure level. |
| Doi | 10.1016/j.chemosphere.2009.01.010 |
| Pmid | 19230956 |
| Wosid | WOS:000266144500012 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Deer mouse; Royal demolition explosive; Hexahydro-1,3,5-trinitroso-1,3,5-triazine; Hexahydro-1,3,5-trinitro-1,3,5-triazine; RDX; TNX |