Toxicokinetics of 14C-RDX in miniature pigs
Reddy, G; Major, MA; Berge, MA; Patzer, S
HERO ID
627880
Reference Type
Journal Article
Subtype
Abstract
Year
2005
| HERO ID | 627880 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 2005 |
| Title | Toxicokinetics of 14C-RDX in miniature pigs |
| Authors | Reddy, G; Major, MA; Berge, MA; Patzer, S |
| Journal | Toxicologist |
| Volume | 84 |
| Issue | S1 |
| Page Numbers | 254 |
| Abstract | Cyclotrimethylenetrinitramine (RDX), a nitramine compound, has been used extensively as an explosive in military munitions since World War II. The toxicokinetic data in animals are limited. In this study, the toxicokinetics of 14C-RDX-derived radioactivity was examined following administration of a single oral dose formulated as an aqueous suspension in 0.1% carboxymethylcellulose at a target dose level of 43 mg/kg (53 μCi/kg) to male and female Yucatan minipigs. Blood was collected at 1, 6, 12 and 24 hours postdose from each animal. Urine and feces were collected through 24 hours postdose. Animals were sacrificed at 24 hours postdose and selected tissues collected. Blood, plasma, tissues, and excreta were analyzed for total radioactivity. Female minipigs vomited and experienced tremors and convulsions within 1 hour postdose. Only vomiting was observed in male minipigs, occurring within 2 hours postdose. Animals appeared normal by 2.5 hours postdose. Urine was the major route for elimination of 14C-RDX-derived radioactivity, with 17.3 and 17.6% of the radioactive dose, respectively, in males and females. RDX was well absorbed. Feces accounted for less than 1% of administered dose and gastrointestinal contents for about 5.6% of the dose. The distribution of 14C-RDXderived radioactivity was extensive, with radioactivity observed in all collected tissues. The highest concentrations of radioactivity were observed in liver and kidney. The calculated percent of radioactive dose was high in liver (3.5 to 5.8%) and muscle (2.5 to 4.7%). Profiling and metabolite identification in urine, plasma, and selected tissues are in progress. |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Name | Society of Toxicology Annual Meeting |
| Is Public | Yes |
| Is Qa | No |