Lack of manifestation of toxicity in rats inhaling 111 ppm 1,4-dioxane for two years
Torkelson, TR; Leong, BKJ; Kociba, RJ; Richter, WA; Gehring, PJ
HERO ID
62958
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 62958 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Lack of manifestation of toxicity in rats inhaling 111 ppm 1,4-dioxane for two years |
| Authors | Torkelson, TR; Leong, BKJ; Kociba, RJ; Richter, WA; Gehring, PJ |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 86 |
| Abstract | Repeated 7-hr daily exposures to an average concentration of 111 ppm (0.4 mg/liter) 1,4-dioxane vapors were given 5 days/week for 2 years to groups of 288 male and 288 female Wistar strain rats. Groups of 192 male and 192 female rats similarly exposed to filtered room air served as controls. There were no observable compound-related effects with respect to demeanor, growth or mortality rate. Hematological studies during the 18th and 23rd months of exposure revealed no deviations from controls. Clinical chemical values determined at the termination of the experiment were within normal limits. Gross and microscopic examination of the major organs and tissues revealed no treatment-related lesions. In this study, no hepatic or nasal carcinomas were observed, although they have been reported to occur in rats maintained on water containing higher levels of dioxane. The incidence of all types of tumors in the control and exposed groups was not statistically different. |
| Url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-18844473725&partnerID=40&md5=2fc15b328cca97ce506c7952c0e74598 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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