Dermal absorption of 14C-cyclotrimethylenetrinitramine (RDX) through human skin
Allen, N; Reddy, G; Major, M
| HERO ID | 630058 |
|---|---|
| In Press | No |
| Year | 2002 |
| Title | Dermal absorption of 14C-cyclotrimethylenetrinitramine (RDX) through human skin |
| Authors | Allen, N; Reddy, G; Major, M |
| Journal | International Journal of Toxicology |
| Volume | 21 |
| Issue | 6 |
| Page Numbers | 519 |
| Abstract | Dermal exposure of RDX and other nitroaromatics is a major concern for the military. There is no information on dermal absorption of RDX in humans for risk assessment. We studied dermal absorption of RDX in human skin in vitro in flow-through diffusion cells. RDX (38.46 microg/0.5 microCi) in acetone (10 microl) was applied to the skin and collected as diffused receptor fluid for every 6 hr up to 24 hrs. The unabsorbed RDX was washed with soap water and water with cotton swabs, and radioactivity present in washings was determined. The RDX absorbed or penetrated in the skin was also determined by separating stratum corneum, epidermis and dermis at the end of the experiments. |
| Doi | 10.1080/10915810260435276 |
| Url | http://ijt.sagepub.com/cgi/doi/10.1080/10915810260435276 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Is Qa | No |