Role of myelofibrosis in hematotoxicity of munitions RDX environmental degradation product MNX. 2009 Update
Meyer, SA
| HERO ID | 630114 |
|---|---|
| Year | 2009 |
| Title | Role of myelofibrosis in hematotoxicity of munitions RDX environmental degradation product MNX. 2009 Update |
| Authors | Meyer, SA |
| Publisher Text | University of Louisiana at Monroe |
| City | Monroe, LA |
| Abstract | The purpose of this research is to determine mechanisms through which hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX), environmental degradation product of munition hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), causes anemia after acute exposure in the rat and examine whether similar effects were elicited by subchronic exposure. We have hypothesized MNX targets hematopoeitic stem cells and, like other myelosuppre-sive chemicals, will be fibrogenic to bone marrow. During this reporting period, results from subchronic exposure in which rats were treated orally with ¼ LD50 MNX daily for 4 or 6 weeks were: 1) significant increases in granulo-cytes and platelets, but not erythrocytes, at both times, 2) an increase in serum K and decreases in Na, Cl, glucose, and creatinine levels in the absence of effect on body weight gain and serum albumin, 3) increased liver weights and 4) increased megakaryocytes in bone marrow, but not fibrosis as indicated by methenamine silver |
| Report Number | W81XWH-05-1-0537 |
| Url | https://ntrl.ntis.gov/NTRL/dashboard/searchResults.xhtml?searchQuery=ADA517261 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Is Qa | No |