Comparative analysis of the toxicological databases for 6:2 fluorotelomer alcohol (6:2 FTOH) and perfluorohexanoic acid (PFHxA)
Rice, PA; Aungst, J; Cooper, J; Bandele, O; Kabadi, SV
HERO ID
6326943
Reference Type
Journal Article
Subtype
Review
Year
2020
Language
English
PMID
| HERO ID | 6326943 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2020 |
| Title | Comparative analysis of the toxicological databases for 6:2 fluorotelomer alcohol (6:2 FTOH) and perfluorohexanoic acid (PFHxA) |
| Authors | Rice, PA; Aungst, J; Cooper, J; Bandele, O; Kabadi, SV |
| Journal | Food and Chemical Toxicology |
| Volume | 138 |
| Page Numbers | 111210 |
| Abstract | 6:2 Fluorotelomer alcohol (6:2 FTOH) is a short-chain polyfluoroalkyl substance (PFAS) in polymeric PFAS used in fast food packaging and stain- and water-resistant textiles and may be degradation products of some components of aqueous film-forming foams (AFFF). The general population is exposed to 6:2 FTOH by inhalation of evaporates from treated surfaces or ambient concentrations in air, ingestion of indoor dust, or ingestion of food packaged in materials containing PFAS. Although exposure to 6:2 FTOH is pervasive, little is known concerning human health effects of this compound. Some published risk assessments have assumed that perfluorohexanoic acid (PFHxA), a metabolite of 6:2 FTOH, adequately models the human health effects of 6:2 FTOH. Recently identified studies conducted with 6:2 FTOH and its metabolite, 5:3 acid, have provided information that enables comparison of the toxicological profiles of PFHxA and 6:2 FTOH. This article summarizes a comparative analysis of the toxicological effects of PFHxA and 6:2 FTOH in rodents to determine whether data for PFHxA adequately models potential hazards of 6:2 FTOH exposure. Our analysis demonstrates that 6:2 FTOH is significantly more toxic than PFHxA. Use of toxicological studies conducted with PFHxA to assess 6:2 FTOH exposure may significantly underestimate human health risk. |
| Doi | 10.1016/j.fct.2020.111210 |
| Pmid | 32087313 |
| Wosid | WOS:000542938400010 |
| Url | http://www.sciencedirect.com/science/article/pii/S0278691520300983 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | 6:2 fluorotelomer alcohol; 5:3 acid; 6:2 FTOH; Perfluorohexanoate; Perfluorohexanoic |