Biological monitoring of isocyanates and related amines: III test chamber exposure of humans to toluene diisocyanate
Skarping, G; Brorson, T; Sango, C
| HERO ID | 63930 |
|---|---|
| In Press | No |
| Year | 1991 |
| Title | Biological monitoring of isocyanates and related amines: III test chamber exposure of humans to toluene diisocyanate |
| Authors | Skarping, G; Brorson, T; Sango, C |
| Journal | International Archives of Occupational and Environmental Health |
| Volume | 63 |
| Issue | 2 |
| Page Numbers | 83-88 |
| Abstract | Five men were exposed to toluene diisocyanate (TDI) atmospheres for 7.5 h. The TDI atmospheres were generated by a gas-phase permeation method, and the exposures were performed in an 8-m3 stainless-steel test chamber. The mean air concentration of TDI was ca. 40 μg/m3, which corresponds to the threshold limit value (TLV) of Sweden. The inhaled doses of 2,4- and 2,6-TDI were ca. 120 μg. TDI in the test chamber air was determined by an HPLC method using the 9-(N-methyl-aminomethyl)-anthracene reagent and by a continuous-monitoring filter-tape instrument. After hydrolysis of plasma and urine, the related amines, 2,4- and 2,6-toluenediamine 2,4-, and 2,6-TDA), were determined as pentafluoropropionic anhydride (PFPA) derivatives by capillary gas-chromatography using selected ion monitoring (SIM) in the electron-impact mode. The urinary elimination of the TDAs showed a possible biphasic pattern, with rapid first phases for 2,4-TDA (mean t 1/2 for the concentration in urine, 1.9 h) and for 2,6-TDA (mean t 1/2 for the concentration in urine, 1.6 h). The cumulative amount of 2,4-TDA excreted in urine within 28 h ranged from 8% to 14% of the estimated dose of 2,4-TDI, and the cumulative amount of 2,6-TDA in urine ranged from 14% to 18% of the 2,6-TDI dose. The average urinary level of 2,4-TDA was 5 μg/l in the 6 to 8-h sample (range 2.8–9.6 μg/l), and the corresponding value for 2,6-TDA was 8.6 μg/l (range, 5.6–16.6 μg/l). Biological monitoring of exposure to 2,4- and 2,6-TDI by analysis of 2,4- and 2,6-TDA in urine is feasible. |
| Doi | 10.1007/BF00379069 |
| Pmid | 1653771 |
| Wosid | WOS:A1991FU35500001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Int. Arch. Occup. Environ. Health 63: 83-88.Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025882379&doi=10.1007%2fBF00379069&partnerID=40&md5=d8c7f68232b8cca771b8db0a9519d79d |
| Is Public | Yes |
| Language Text | English |
| Keyword | TOLUENE DIISOCYANATE, TDI; TOLUENEDIAMINE, TDA; TEST CHAMBER; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; BIOLOGICAL MONITORING |
| Is Qa | No |
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