Strain A mouse pulmonary tumor test results for chemicals previously tested in the National Cancer Institute carcinogenicity tests
Maronpot, RR; Shimkin, MB; Witschi, HP; Smith, LH; Cline, JM
HERO ID
64404
Reference Type
Journal Article
Year
1986
Language
English
PMID
| HERO ID | 64404 |
|---|---|
| In Press | No |
| Year | 1986 |
| Title | Strain A mouse pulmonary tumor test results for chemicals previously tested in the National Cancer Institute carcinogenicity tests |
| Authors | Maronpot, RR; Shimkin, MB; Witschi, HP; Smith, LH; Cline, JM |
| Journal | Journal of the National Cancer Institute |
| Volume | 76 |
| Issue | 6 |
| Page Numbers | 1101-1112 |
| Abstract | ABSTRACT - Sixty-five chemicals were coded and examined for their ability to induce lung tumors in strain A/St (laboratory A) or strain AJ (laboratory B) mice. Thirty-five chemicals were tested in laboratory A only, 8 in laboratory B only, and 24 in both laboratories. Two-year carcinogenicity test results as well as genotoxicity test data are available for most of these chemicals. There was poor interlaboratory agreement in strain A test results for the 24 chemicals tested in both laboratories. In addition, there was poor agreement between strain A test results from either laboratory and 2-year carcinogenicity test results or genotoxicity results. Possible explanations for these findings include selection of a large number of aromatic amines in the group of chemicals submitted for strain A testing, differences in strain A testing protocols and in statistical analysis of results from the two laboratories, low sensitivity of the strain A/St mice used in this particular study, and general problems inherent in comparing any relatively short-term animal tumor model with 2-year carcinogenicity tests. Since there is no absolute reference for carcinogenicity, no one test system is better than another. Carcinogenicity test data are relevant only to the test model employed.-JNCI 1986; 76:1101-1112. |
| Pmid | 3458947 |
| Wosid | WOS:A1986C820900018 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.JNCI J. Natl. Cancer Inst. 76: 1101-1112. |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |