Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity
Elfarra, AA; Jakobson, I; Anders, MW
HERO ID
64811
Reference Type
Journal Article
Year
1986
Language
English
PMID
| HERO ID | 64811 |
|---|---|
| In Press | No |
| Year | 1986 |
| Title | Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity |
| Authors | Elfarra, AA; Jakobson, I; Anders, MW |
| Journal | Biochemical Pharmacology |
| Volume | 35 |
| Issue | 2 |
| Page Numbers | 283-288 |
| Abstract | S-(1,2-Dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-DL-cysteine are potent nephrotoxins. Agents that inhibit gamma-glutamyl transpeptidase, cysteine conjugate beta-lyase, and renal organic anion transport systems, namely L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125), aminooxyacetic acid, and probenecid, respectively, protected against S-conjugate-induced nephrotoxicity. Furthermore, S-(1,2-dichlorovinyl)-DL-alpha-methylcysteine, which cannot be cleaved by cysteine conjugate beta-lyase, was not nephrotoxic. These results strongly support a role for renal gamma-glutamyl transpeptidase, cysteine conjugate beta-lyase, and organic anion transport systems in S-(1,2-dichlorovinyl)glutathione- and S-(1,2-dichlorovinyl)cysteine-induced nephrotoxicity. |
| Pmid | 2867768 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | S in S-(1,2-dichlorovinyl) is italicized.Biochem. Pharmacol. 35: 283-288. |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |