Long-term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague-Dawley rats and Swiss and B6C3F1 mice
Maltoni, C; Lefemine, G; Cotti, G; Perino, G
HERO ID
65264
Reference Type
Journal Article
Year
1988
Language
English
PMID
| HERO ID | 65264 |
|---|---|
| In Press | No |
| Year | 1988 |
| Title | Long-term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague-Dawley rats and Swiss and B6C3F1 mice |
| Authors | Maltoni, C; Lefemine, G; Cotti, G; Perino, G |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 534 |
| Page Numbers | 316-342 |
| Abstract | Trichloroethylene was administered by inhalation, 7 hours daily, 5 days weekly, for 8 weeks, at concentrations of 600, 100 and 0 ppm, to Sprague-Dawley rats and Swiss mice; and for 104 weeks to Sprague-Dawley rats; and for 78 weeks to Swiss and B6C3F1 mice at concentrations of 600, 300, 100 and 0 ppm. The animals were kept under observation until spontaneous death. In the experiments reported herein, 3768 animals were studied. Under the experimental conditions, trichloroethylene appears to be carcinogenic in rats and mice (particularly in male Swiss mice). The most relevant finding was the dose-related increased incidence of Leydig cell tumors in male rats, and the onset of few renal tubuli adenocarcinomas at the highest dose, always in rats (4/130 males and 1/130 females). The renal tubuli adenocarcinomas were preceded by, and associated with, a characteristic lesion of the kidney: tubuli cell karyomegaly (megalonucleocytosis). |
| Doi | 10.1111/j.1749-6632.1988.tb30120.x |
| Pmid | 3389663 |
| Wosid | WOS:A1988Q080100028 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: MALTONI ISSN: |
| Is Public | Yes |
| Language Text | English |