Adipose tissue concentrations of persistent organic pollutants and the risk of prostate cancer
Hardell, L; Andersson, SO; Carlberg, M; Bohr, L; van Bavel, B; Lindstrom, G; Bjornfoth, H; Ginman, C
HERO ID
652802
Reference Type
Journal Article
Year
2006
Language
English
PMID
| HERO ID | 652802 |
|---|---|
| In Press | No |
| Year | 2006 |
| Title | Adipose tissue concentrations of persistent organic pollutants and the risk of prostate cancer |
| Authors | Hardell, L; Andersson, SO; Carlberg, M; Bohr, L; van Bavel, B; Lindstrom, G; Bjornfoth, H; Ginman, C |
| Journal | Journal of Occupational and Environmental Medicine |
| Volume | 48 |
| Issue | 7 |
| Page Numbers | 700-707 |
| Abstract | OBJECTIVE: We sought to study the concentrations of certain persistent organic pollutants with endocrine-disrupting properties in cases with prostate cancer and controls with benign prostate hyperplasia. METHODS: Adipose tissue was obtained from 58 cases and 20 controls. RESULTS: The median concentration among controls was used as cut-off in the statistical analysis. In the total material, a greater-than median concentration of PCB congener 153 yielded an odds ratio (OR) of 3.15 and 95% confidence interval (CI) of 1.04-9.54 and one chlordane type, trans-chlordane, yielded OR 3.49 (95% CI = 1.08-11.2). In the group of case subjects with PSA levels greater than the median level of 16.5 ng/mL, PCB 153 was OR 30.3 (95% CI = 3.24-284), hexachlorobenzene OR = 9.84 (95% CI = 1.99-48.5), trans-chlordane OR = 11.0 (95% CI = 1.87-64.9), and the chlordane-type MC6 OR = 7.58 (95% CI = 1.65-34.9). The grouping of PCBs according to structural and biological activity was found to produce significantly increased risks for enzyme and phenobarbital-inducing PCBs and lower chlorinated PCBs in the case group with PSA levels greater than 16.5 ng/mL. CONCLUSIONS: These chemicals might be of etiologic significance but need to be further investigated. The biological relevance of the arbitrary cut-off point of PSA is unclear. |
| Doi | 10.1097/01.jom.0000205989.46603.4 |
| Pmid | 16832227 |
| Wosid | WOS:000239137000013 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Adipose Tissue/ physiology; Aged; Aged, 80 and over; Humans; Male; Middle Aged; Occupational Exposure; Polychlorinated Biphenyls/metabolism; Prostate-Specific Antigen/analysis; Prostatic Hyperplasia/ etiology; Risk Assessment; State Medicine; Sweden |
| Is Qa | No |