Effect of halocarbons and styrene on thrombin and calcium ionophore induced activation of rabbit platelets
Yamazaki, H; Yamaguchi, T; Yamauchi, A; Kakiuchi, Y
HERO ID
658888
Reference Type
Journal Article
Year
1992
Language
English
| HERO ID | 658888 |
|---|---|
| In Press | No |
| Year | 1992 |
| Title | Effect of halocarbons and styrene on thrombin and calcium ionophore induced activation of rabbit platelets |
| Authors | Yamazaki, H; Yamaguchi, T; Yamauchi, A; Kakiuchi, Y |
| Journal | Chemosphere |
| Volume | 25 |
| Issue | 5 |
| Page Numbers | 665-673 |
| Abstract | BIOSIS COPYRIGHT: BIOL ABS. The series of study about the effect of environmental pollutants on cell functions, the influence of several volatile halocarbons (trichloroethylene, tetrachloroethylene, trichloroethanol, bromodichlomethane, chlorodibromomethane and bromoform) and styrene on calcium ionophore (A-23187) or thrombin induced activation of washed rabbit platelets has been examined. Platelet activation was measured by thromboxane B2 synthesis. As a result, tetrachloroethylene and trichloethanol inhibited both A-23187 and thrombin induced platelet activation significantly. Bromoform had an inhibitory action at its highest concentration (10uM) against A-23187 induced platelet activation. Styrene and bromoform revealed a strong inhibitory action against thrombin induced platelet activation. There seemed to be no concentration dependent inhibition of these compounds against platelet activation induced by both agonists. When platelet was pretreated with these compounds, all compounds except tri |
| Doi | 10.1016/0045-6535(92)90429-U |
| Wosid | WOS:A1992JR97300004 |
| Url | <Go to ISI>://WOS:A1992JR97300004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | Animals;Cytology;Histocytochemistry;Biochemistry;Amino acids;Peptides;Proteins;Minerals;Enzymes physiology;Blood chemical analysis;Body fluids chemistry;Lymph chemistry;Blood cells ultrastructure;Blood cells physiology;Blood cells chemistry;Poisoning;laboratory;Environmental pollutants poisoning;Occupational diseases;Air pollution;Soil pollutants;Water pollution;Lagomorpha;127-18-4;124-48-1;115-20-8;100-42-5;79-01-6;75-27-4;75-25-2 |
| Is Qa | No |