Pathological excretion patterns of urinary proteins in miners highly exposed to dinitrotoluene
Bruning, T; Thier, R; Mann, H; Melzer, H; Brode, P; Dallner, G; Bolt, HM
HERO ID
662203
Reference Type
Journal Article
Year
2001
Language
English
PMID
| HERO ID | 662203 |
|---|---|
| In Press | No |
| Year | 2001 |
| Title | Pathological excretion patterns of urinary proteins in miners highly exposed to dinitrotoluene |
| Authors | Bruning, T; Thier, R; Mann, H; Melzer, H; Brode, P; Dallner, G; Bolt, HM |
| Journal | Journal of Occupational and Environmental Medicine |
| Volume | 43 |
| Issue | 7 |
| Page Numbers | 610-615 |
| Abstract | A cohort of 161 underground miners who had been highly exposed to dinitrotoluene (DNT) in the copper-mining industry of the former German Democratic Republic was reinvestigated for signs of subclin. renal damage. The study included a screening of urinary proteins excreted by SDS-PAGE, and quantitations of the specific urinary proteins ?1-microglobulin and glutathione-S-transferase ? (GST ?) as biomarkers for damage of the proximal tubule and glutathione-S-transferase ? (GST ?) for damage of the distal tubule. The exposures were categorized semiquant. (low, medium, high, and very high), according to the type and duration of professional contact with DNT. A straight dose-dependence of pathol. protein excretion patterns with the semiquant. ranking of DNT exposure was seen. Most of the previously reported cancer cases of the urinary tract, esp. those in the higher exposed groups, were confined to pathol. urinary protein excretion patterns. The damage from DNT was directed toward the tubular system. In many cases, the appearance of Tomm-Horsfall protein, a 105 kDa protein marker, was noted. Data on the biomarkers ?1-microglobulin, GST ?, and GST ? consistently demonstrated a dose-dependent increase in tubular damage, which confirmed the results of screening by SDS-PAGE and clearly indicated a nephrotoxic effect of DNT under the given conditions of exposure. Within the cluster of cancer patients obsd. among the DNT-exposed workers, only in exceptional cases were normal biomarker excretions found. |
| Pmid | 11464391 |
| Wosid | WOS:000169823400007 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |