A toxicological investigation of the acute, subchronic, and chronic effects of administering di-2-ethylhexyl phthalate (DEHP) and other phthalate esters
Lawrence, WH; Malik, M; Turner, JE; Singh, AR; Autian, J
HERO ID
667279
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 667279 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | A toxicological investigation of the acute, subchronic, and chronic effects of administering di-2-ethylhexyl phthalate (DEHP) and other phthalate esters |
| Authors | Lawrence, WH; Malik, M; Turner, JE; Singh, AR; Autian, J |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 87-88 |
| Abstract | Twelve esters of phthalic acid, including some of those most commonly used as plasticizers for biomedical devices, were subjected to one or more biological tests for acute, subchronic, and/or chronic toxicity. Certain aspects of subtle effects were investigated as well as overt toxic manifestations. The acute, ip LD50 of these compounds in mice ranged from 3.22 to more than 100 g/kg. A cornparision of the acute to chronic LD50 values reveals most of these phthalates are 2-4 times more toxic chronically. However, di-n-octyl phthalate (DOP) was almost 22 times more toxic chronically, and the chronic toxicity of di-2-ethylhexyl phthalate (DEHP) was about 28 times greater. Pre-treatment of mice with these phthalate esters generally resulted in an increase in pentobarbital sleeping time. A 12-week subchronic study of di-2-ethylhexyl phthalate in rats revealed very few abnormalities which could be attributed to the phthalate ester. Some of the new data are discussed in relation to previously published results of similar studies. |
| Wosid | WOS:A1974T653800038 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, DC |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10-14, 1974 |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0016257949&partnerID=40&md5=c63e43e26d79ed446476da396e89d1a2 |
| Is Public | Yes |
| Language Text | English |
| Keyword | pentobarbital; phthalic acid bis(2 ethylhexyl) ester; phthalic acid derivative; drug toxicity; intraperitoneal drug administration; LD 50; mouse; sleep time; theoretical study |
| Relationship(s) |
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