Motor hyperactivity caused by a deficit in dopaminergic neurons and the effects of endocrine disruptors: a study inspired by the physiological roles of PACAP in the brain
Masuo, Y; Morita, M; Oka, S; Ishido, M
HERO ID
674405
Reference Type
Journal Article
Year
2004
Language
English
PMID
| HERO ID | 674405 |
|---|---|
| In Press | No |
| Year | 2004 |
| Title | Motor hyperactivity caused by a deficit in dopaminergic neurons and the effects of endocrine disruptors: a study inspired by the physiological roles of PACAP in the brain |
| Authors | Masuo, Y; Morita, M; Oka, S; Ishido, M |
| Journal | Regulatory Peptides |
| Volume | 123 |
| Issue | 1-3 |
| Page Numbers | 225-234 |
| Abstract | Recent studies have revealed that the pituitary adenylate cyclase-activating polypeptide (PACAP) might act as a psychostimulant. Here we investigated the mechanisms underlying motor hyperactivity in patients with pervasive developmental disorders, such as autism, and attention-deficit hyperactivity disorder (ADHD). We studied the effects of intracisternal administration of 6-hydroxydopamine (6-OHDA) or endocrine disruptors (EDs) on spontaneous motor activity (SMA) and multiple gene expression in neonatal rats. Treatment with 6-OHDA caused significant hyperactivity during the dark phase in rats aged 4-5 weeks. Motor hyperactivities also were observed after treatment with endocrine disruptors, such as bisphenol A, nonylphenol, diethylhexyl phthalate and dibutyl phthalate, during both dark and light phases. Gene-expression profiles produced using cDNA macroarrays of 8-week-old rats with 6-OHDA lesions revealed the altered expression of several classes of gene, including the N-methyl-D-aspartate (NMDA) receptor 1, glutamate/aspartate transporter, gamma-aminobutyric-acid transporter, dopamine transporter 1, D4 receptor, and peptidergic elements such as the galanin receptor, arginine vasopressin receptor, neuropeptide Y and tachykinin 2. The changes in gene expression caused by treatment with endocrine disruptors differed from those induced by 6-OHDA. These results suggest that the mechanisms underlying the induction of motor hyperactivity and/or compensatory changes in young adult rats might differ between 6-OHDA and endocrine disruptors. |
| Doi | 10.1016/j.regpep.2004.05.010 |
| Pmid | 15518916 |
| Wosid | WOS:000225154400032 |
| Url | http://www.sciencedirect.com/science/article/pii/S0167011504001752 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Hakone, JAPAN |
| Conference Name | 6th International Symposium on VIP/PACAP |
| Comments | Source: Web of Science WOS:000225154400032 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity/physiopathology; Autistic Disorder/physiopathology; Brain/drug effects/*physiology; Dibutyl Phthalate/toxicity; Diethylhexyl Phthalate/toxicity; Dopamine/*metabolism; Endocrine Glands/drug effects; Gene Expression/drug effects; Humans; Male; Motor Activity/*drug effects/*physiology; Nerve Growth Factors/*physiology; Neurons/drug effects/*metabolism; Neuropeptides/*physiology; Neurotransmitter Agents/*physiology; Oxidopamine/toxicity; Phenols/toxicity; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Wistar; 0 (ADCYAP1 protein, human); 0 (Adcyap1 protein, rat); 0 (Nerve Growth Factors); 0 (Neuropeptides); 0 (Neurotransmitter Agents); 0 (Phenols); 0 (Pituitary Adenylate Cyclase-Activating Polypeptide); 117-81-7 (Diethylhexyl Phthalate); 1199-18-4 (Oxidopamine); 25154-52-3 (nonylphenol); 80-05-7 (bisphenol A); 84-74-2 (Dibutyl Phthalate) |
| Is Qa | No |
| Relationship(s) |
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