Teratogenicity of di(2-ethylhexyl) phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine
Ritter, EJ; Scott, WJ, Jr; Randall, JL; Ritter, JM
HERO ID
674457
Reference Type
Journal Article
Subtype
Abstract
Year
1987
Language
English
PMID
| HERO ID | 674457 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1987 |
| Title | Teratogenicity of di(2-ethylhexyl) phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine |
| Authors | Ritter, EJ; Scott, WJ, Jr; Randall, JL; Ritter, JM |
| Journal | Teratology |
| Volume | 35 |
| Issue | 1 |
| Page Numbers | 41-46 |
| Abstract | It is hypothesized that the teratogen di(2-ethylhexyl) phthalate (DEHP) acts by in vivo hydrolysis to 2-ethylhexanol (2-EHXO), which in turn is metabolized to 2-ethylhexanoic acid (2-EHXA), the proximate teratogen. Teratological studies were conducted with Wistar rats, with administration of these agents on day 12 of gestation. On an equimolar basis DEHP was least potent, 2-EHXO was intermediate, and 2-EXHA was the most potent of the three agents, which is consistent with the hypothesis. Similarity in the types of defects found with these agents also suggests a common mechanism, with 2-EHXA as the proximate teratogen. All three agents were potentiated by caffeine. Valproic acid, which is an isomer of 2-EXHA, also produced similar defects, and was approximately twice as potent as 2-EHXA. |
| Doi | 10.1002/tera.1420350107 |
| Pmid | 3105103 |
| Wosid | WOS:A1987G295200006 |
| Url | https://search.proquest.com/docview/77466615?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Nagoya, Japan |
| Conference Name | Thirty-third Annual Meeting of the Japanese Teratology Society |
| Conference Date | July 21-23, 1993 |
| Comments | Authoring Organization: Senatskommission zur Prèufung gesundheitsschèadlicher Arbeitsstoffe |
| Is Public | Yes |
| Language Text | English |
| Keyword | *Abnormalities, Drug-Induced; Animals; Caffeine/*toxicity; Caproates/*toxicity; Diethylhexyl Phthalate/metabolism/*toxicity; Drug Synergism; Female; Hexanoic Acids/metabolism/*toxicity; Hexanols/metabolism/*toxicity; Maternal-Fetal Exchange; Phthalic Acids/*toxicity; Pregnancy; Rats; Rats, Inbred Strains; Valproic Acid/*toxicity; 0 (Caproates); 0 (Hexanoic Acids); 0 (Hexanols); 0 (Phthalic Acids); 104-76-7 (2-ethylhexanol); 117-81-7 (Diethylhexyl Phthalate); 149-57-5 (2-ethylhexanoic acid); 58-08-2 (Caffeine); 99-66-1 (Valproic Acid) |
| Is Peer Review | Yes |
| Relationship(s) |
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