Perinatal butyl benzyl phthalate (BBP) and bis(2-ethylhexyl)phthalate (DEHP) exposures induce antiandrogenic effects in Sprague-Dawley (SD) rats
Parks, LG; Ostby, JS; Lambright, CR; Abbott, BD; Gray, LE, Jr
HERO ID
675373
Reference Type
Journal Article
Year
1999
Language
English
| HERO ID | 675373 |
|---|---|
| In Press | No |
| Year | 1999 |
| Title | Perinatal butyl benzyl phthalate (BBP) and bis(2-ethylhexyl)phthalate (DEHP) exposures induce antiandrogenic effects in Sprague-Dawley (SD) rats |
| Authors | Parks, LG; Ostby, JS; Lambright, CR; Abbott, BD; Gray, LE, Jr |
| Journal | Biology of Reproduction |
| Volume | 60 |
| Issue | Suppl 1 |
| Page Numbers | 153 |
| Abstract | The developmental effects of several endocrine disrupting chemicals that act as androgen receptor (AR) antagonists have been described in our laboratory. While Mylchreest et al. (1998) and Gray et al. (1999) reported that BBP and DEHP produced antiandrogenic effects on male sexual differentiation, studies by Lambright et al. (1999) indicated that DBP and DEHP are not AR antagonists. Although some phthalates like BBP are weakly estrogenic in vitro, this mechanism seems unlikely to explain the developmental alterations because the phthalates do not display estrogenicity in vivo. This study was conducted to determine if BBP and DEHP induce reproductive tract malformations and to identify the mechanisms of action. SD rats were dosed by gavage with 750 mg/kg/d of BBP, DEHP or corn oil from gestational day 14 to postnatal day (PND) 3. On PND-2 anogenital distance (AGD), testes weight and in vitro testosterone (T) production were measured. Testes weights and AGD were significantly decreased for both DEHP and BBP exposed pups and the incidence of areolas (PND-13) was increased. Further, T production was reduced by DEHP treatment. These antiandrogenic-like effects may result from reduced androgen production in the fetal Leydig cells and suggests that the testis is the target organ directly affected by perinatal phthalate exposure. It remains to be determined whether these effects are mediated via direct action of the phthalates on the fetal Leydig cells or through alterations of Sertoli cell paracrine secretions. |
| Wosid | WOS:000081141300256 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Authoring Organization: ARTHUR D LITTLE INC |
| Is Public | Yes |
| Language Text | English |
| Keyword | Pregnancy; Rats; Animal; Female; Sprague-Dawley; Androgen Antagonists TOXICITY; Phthalic Acids TOXICITY; Diethylhexyl Phthalate TOXICITY; Fetus DRUG EFFECTS; Testis DRUG EFFECTS; Organ Weight DRUG EFFECTS; Testosterone BIOSYNTHESIS; No cas rn; 85-68-7; 117-81-7; 57-85-2 |
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