An updated review of environmental estrogen and androgen mimics and antagonists
Sonnenschein, C; Soto, AM
HERO ID
675432
Reference Type
Journal Article
Subtype
Review
Year
1998
Language
English
PMID
| HERO ID | 675432 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 1998 |
| Title | An updated review of environmental estrogen and androgen mimics and antagonists |
| Authors | Sonnenschein, C; Soto, AM |
| Journal | Journal of Steroid Biochemistry and Molecular Biology |
| Volume | 65 |
| Issue | 1-6 |
| Page Numbers | 143-150 |
| Abstract | BIOSIS COPYRIGHT: BIOL ABS. For the last 40 y, substantial evidence has surfaced on the hormone-like effects of environmental chemicals such as pesticides and industrial chemicals in wildlife and humans. The endocrine and reproductive effects of these chemicals are believed to be due to their ability to: (1) mimic the effect of endogenous hormones, (2) antagonize the effect of endogenous hormones, (3) disrupt the synthesis and metabolism of endogenous hormones, and (4) disrupt the synthesis and metabolism of hormone receptors. The discovery of hormone-like activity of these chemicals occurred long after they were released into the environment. Aviation crop dusters handling DDT were found to have reduced sperm counts, and workers at a plant producing the insecticide kepone were reported to have lost their libido, became impotent and had low sperm counts. Subsequently, experiments conducted in lab animals demonstrated unambiguously the estrogenic activity of these pesticides. Manmade compounds used |
| Doi | 10.1016/S0960-0760(98)00027-2 |
| Pmid | 9699867 |
| Wosid | WOS:000074830800014 |
| Url | http://www.sciencedirect.com/science/article/pii/S0960076098000272 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000074830800014 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Biochemistry; Diagnosis; Genitalia; Reproduction; poisoning; Animals; laboratory; Public Health; 79881-34-8; 70362-47-9; 70362-41-3; 67651-37-0; 67651-36-9; 67651-34-7; 55702-46-0; 55702-45-9; 53905-30-9; 53905-29-6; 53905-28-5; 51235-04-2; 51218-45-2; 40596-69-8; 38444-81-4; 38411-22-2; 35694-04-3; 34883-41-5; 34883-39-1; 33284-54-7; 33284-53-6; 33213-65-9; 33146-45-1; 33025-41-1; 32598-12-2; 29082-74-4; 25013-16-5; 22781-23-3; 21725-46-2; 18259-05-7; 15972-60-8; 14962-28-8; 12789-03-6; 12427-38-2; 9006-42-2; 8003-34-7; 8001-35-2; 6164-98-3; 5335-24-0; 3424-82-6; 2921-88-2; 2385-85-5; 2051-62-9; 2051-60-7; 2051-24-3; 2008-41-5; 1918-02-1; 1912-24-9; 1897-45-6; 1861-32-1; 1746-01-6; 1582-09-8; 1563-66-2; 1459-93-4; 1137-59-3; 959-98-8; 789-02-6; 580-51-8; 333-41-5; 143-50-0; 139-40-2; 131-18-0; 128-37-0; 127-18-4; 122-34-9; 121-75-5; 120-61-6; 118-74-1; 115-32-2; 115-29-7; 100-42-5; 94-82-6; 94-75-7; 92-69-3; 90-43-7; 88-85-7; 85-68-7; 84-76-4; 84-74-2; 83-79-4; 80-05-7; 78-87-5; 76-44-8; 72-43-5; 63-25-2; 60-57-1; 58-89-9; 56-38-2; 50-29-3 |
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