Mechanism of testicular atrophy induced by di-n-butyl phthalate in rats. Part 2. The effects on some testicular enzymes
Fukuoka, M; Zhou, Y; Tanaka, A; Ikemoto, I; Machida, T
HERO ID
675892
Reference Type
Journal Article
Year
1990
Language
English
PMID
| HERO ID | 675892 |
|---|---|
| In Press | No |
| Year | 1990 |
| Title | Mechanism of testicular atrophy induced by di-n-butyl phthalate in rats. Part 2. The effects on some testicular enzymes |
| Authors | Fukuoka, M; Zhou, Y; Tanaka, A; Ikemoto, I; Machida, T |
| Journal | Journal of Applied Toxicology |
| Volume | 10 |
| Issue | 4 |
| Page Numbers | 285-293 |
| Abstract | A single oral dose of di-n-butyl phthalate (DBP) to male rats caused histologically a sloughing of the germ cells at 6 h. On Days 1 and 2 more severe sloughing was seen, followed by atrophy and the dissociationof the germ cells from the Sertoli cells and the spermatogonia. Biochemically, there was elevation of y-glutamyl transferase, a decrease in sorbitol levels at 3 h and a decrease in the activity of aldose reductase at 6 h, in the testes of treated rats. This was followed by decreases in fructose levels and increases in the activity of lactate dehydrogenase (LDH) and in lactate levels at 12 h , and decreases in the activities of sorbitol dehydrogenase and succinate dehydrogenase on Day 2. LDH isoenzymes 4 and 6 increased at 6 h prior to the increase in lactate levels. Increases in the levels of inositol and the activities of alkaline phosphatase and lactate dehdryogenase were also observed. Thus, these data suggest that DBP-induced testicular toxicity is caused by a shortage of energy fuels from glucose metabolism or by an anoxia. |
| Doi | 10.1002/jat.2550100410 |
| Pmid | 2391408 |
| Wosid | WOS:A1990DT92900009 |
| Url | https://search.proquest.com/docview/79964809?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Di-n-butyl phthalate; rat testicular atrophy; testicular enzymes; glucose; fructose; inositol; cholesterol |
| Is Peer Review | Yes |
| Relationship(s) |
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