Estimated exposure to phthalates in cosmetics and risk assessment
Koo, HJ; Lee, BM
HERO ID
675976
Reference Type
Journal Article
Year
2004
Language
English
PMID
| HERO ID | 675976 |
|---|---|
| In Press | No |
| Year | 2004 |
| Title | Estimated exposure to phthalates in cosmetics and risk assessment |
| Authors | Koo, HJ; Lee, BM |
| Journal | Journal of Toxicology and Environmental Health, Part A: Current Issues |
| Volume | 67 |
| Issue | 23-24 |
| Page Numbers | 1901-1914 |
| Abstract | Some phthalates such as di(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) and their metabolites are suspected of producing teratogenic or endocrine-disrupting effects. To predict possible human exposure to phthalates in cosmetics, the levels of DEHP, diethyl phthalate (DEP), DBP and butylbenzyl phthalate (BBP) were determined by high-performance liquid chromatography (HPLC) in 102 branded hair sprays, perfumes, deodorants and nail polishes. DBP was detected in 19 of the 21 nail polishes and in 11 of the 42 perfumes, and DEP was detected in 24 of the 42 perfumes and 2 of the 8 deodorants. Median exposure levels to phthalates in cosmetics by derman absorption were estimated to be 0.0006 micrograms/kg body weight (bw)/d for DEHP, 0.6 micrograms/kg bw/d for DEP, and 0.103 micrograms/kg bw/d for DBP. Furthermore, if phthalates in cosmetics were assumed to absorbed exclusively via 100% inhalation, the median daily exposure levels to phthalates in cosmetics were estimated to be 0.026 micrograms/kg bw/d for DEHP, 81.471 micrograms/kg bw/d for DEP, and 22.917 micrograms/kg bw/d for DBP, which are far lower than the regulation levels set by the Scientific Committee on Toxicity, Ecotoxicity, and the Environment (CSTEE) (37 micrograms/kg bw/d, DEHP), Agency for Toxic Substances and Disease Registry (ATSDR) (7000 micrograms/kg bw/d, DEP), and International Programme on Chemical Safety (IPCS) (66 micrograms/kg bw/d, DBP), respectively. Based on these data, hazard indices (HI, daily exposure level/regulation level) were calculated to be 0.0007 for DEHP, 0.012 for DEP, and 0.347 for DBP. These data suggest that estimated exposure to phthalates in the cosmetics mentioned are relatively small. However, total exposure levels from several sources may be greater and require further investigation. |
| Doi | 10.1080/15287390490513300 |
| Pmid | 15513891 |
| Wosid | WOS:000225105900001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Proquest URL: https://search.proquest.com/docview/67182296?accountid=171501 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
|