Effect of phthalate esters on drug metabolizing enzyme activities in rat liver
Aitio, A; Parkki, M
HERO ID
679138
Reference Type
Journal Article
Year
1978
Language
English
PMID
| HERO ID | 679138 |
|---|---|
| In Press | No |
| Year | 1978 |
| Title | Effect of phthalate esters on drug metabolizing enzyme activities in rat liver |
| Authors | Aitio, A; Parkki, M |
| Journal | Archives Internationales de Pharmacodynamie et de Thérapie |
| Volume | 235 |
| Issue | 2 |
| Page Numbers | 187-195 |
| Abstract | Dibutyl-, di(2-ethylhexyl)-, di(3, 3, 5-trimethylhexyl)- and didecylphthalate (DBP, DEHP, TMHP, DDP) all caused an increase in the amount of hepatic cytochrome P=450, when administered intragastrically to rats. No statistically significant increase could be detected in the catalytic activities dependent on cytochrome P-450 (Benzo(a)pyrene hydroxylation, ethoxycoumarin deethylation). Dibutylphthalate inhibited these reactions, when added to the incubation in vitro. Phthalates caused an increase in the activities of epoxide hydratase, and glutathione-S-transferase. Conjugation of 0-aminophenol and 4-methylumbelliferone with glucuronic acid was increased after phthalate administration. |
| Pmid | 736698 |
| Wosid | WOS:A1978GD82700002 |
| Url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0018072569&partnerID=40&md5=46134c5541a06b66258428c893da4e5f |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Authoring Organization: EG and G BIONOMICS |
| Is Public | Yes |
| Language Text | English |
| Keyword | Animals; Benzo(a)pyrene; drug effects; enzymology; Esters; Hydroxylation; Liver; Male; metabolism; Microsomes,Liver; Mixed Function Oxygenases; Oxygenases; Pharmaceutical Preparations; pharmacology; Phthalic Acids; Rats; CITED_2009 |
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