Effects of endocrine disruptors on arachidonic acid metabolism in rabbit platelets
Fujimoto, Y; Sakuma, S; Nishiwaki, Y; Ikeda, M; Fujita, T
HERO ID
679521
Reference Type
Journal Article
Year
2003
Language
English
PMID
| HERO ID | 679521 |
|---|---|
| In Press | No |
| Year | 2003 |
| Title | Effects of endocrine disruptors on arachidonic acid metabolism in rabbit platelets |
| Authors | Fujimoto, Y; Sakuma, S; Nishiwaki, Y; Ikeda, M; Fujita, T |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 189 |
| Issue | 2 |
| Page Numbers | 96-99 |
| Abstract | To explore the possible actions of endocrine disruptors on the autacoid synthesis in the body, we investigated the effects of nonylphenol (NP), bisphenol A (BPA), di-n-butyl phthalate (DBP), benzyl-n-butyl phthalate (BBP), and di-2-ethylhexyl phthalate (DEHP) on the formation of 12-lipoxygenase metabolite, 12-HETE, and cyclooxygenase metabolites, TXB(2) and 12-HHT, from exogenous arachidonic acid (AA) in rabbit platelets. NP (10-50 microM) showed strong inhibition on the formation of cyclooxygenase metabolites (TXB(2), 34-95% inhibition; 12-HHT, 13-78% inhibition) and weaker inhibition on the formation of 12-HETE (0-49% inhibition). BPA, DBP, BBP, DEHP, and 17beta-estradiol (endogenous estrogen) failed to show any effect on the formation of cyclooxygenase and 12-lipoxygenase metabolites at concentrations up to 100 microM. These results suggest that NP inhibits AA metabolism in platelets and that its effects on the cyclooxygenase pathway predominate over those exerted via the 12-lipoxygenase pathway |
| Doi | 10.1016/S0041-008X(03)00095-4 |
| Pmid | 12781627 |
| Wosid | WOS:000183360700003 |
| Url | https://search.proquest.com/docview/18792206?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000183360700003 |
| Is Public | Yes |
| Language Text | English |
| Keyword | 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; antagonists & inhibitors; Arachidonate 12-Lipoxygenase; Arachidonic Acid; blood; Blood Platelets; chemistry; drug effects; Endocrine Disruptors; Endocrine System; Enzyme Inhibitors; enzymology; Fatty Acids; Fatty Acids,Unsaturated; Japan; Male; metabolism; pharmacology; Prostaglandin-Endoperoxide Synthases; Rabbits; Thromboxane B2 |
| Is Qa | No |