Effects of maternal exposure to di-isononylphthalate (DINP) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) on steroidogenesis in the fetal rat testis and adrenal gland
Adamsson, A; Salonen, V; Paranko, J; Toppari, J
HERO ID
679859
Reference Type
Journal Article
Year
2009
Language
English
PMID
| HERO ID | 679859 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | Effects of maternal exposure to di-isononylphthalate (DINP) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) on steroidogenesis in the fetal rat testis and adrenal gland |
| Authors | Adamsson, A; Salonen, V; Paranko, J; Toppari, J |
| Journal | Reproductive Toxicology |
| Volume | 28 |
| Issue | 1 |
| Page Numbers | 66-74 |
| Abstract | Exposure to antiandrogens during the critical developmental window (i.e. sexual differentiation) can permanently demasculinize the male phenotype. Here we have investigated the effects of developmental exposure to di-isononylphthalate (DINP) (250 and 750 mg/kg) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) (50 and 100mg/kg) on 19.5-day-old fetal Sprague-Dawley rat testicular and adrenal steroidogenesis. Maternal exposure to DINP or p,p'-DDE on embryonic days (EDs) 13.5-17.5 did not down-regulate the activity of steroidogenesis in ED 19.5 male rat fetus. Protein expression levels of testicular and adrenal StAR, P450scc, 3beta-HSD and androgen receptor (AR) did not show any changes. However, p,p'-DDE caused clear abnormalities in the ultrastructure of steroidogenic cells in ED 19.5 rat testis and adrenal. These structural alterations can disturb the development and function of fetal testis and adrenal that may become evident later in life. |
| Doi | 10.1016/j.reprotox.2009.03.002 |
| Pmid | 19490997 |
| Wosid | WOS:000267198600010 |
| Url | https://search.proquest.com/docview/67323946?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: Reproductive toxicology (Elmsford, N.Y.) ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene; Adrenal; Di-isononylphthalate; Environmental antiandrogen; Steroidogenesis; 1,1 dichloro 2,2 bis(4 chlorophenyl)ethylene; 3(or 17)beta hydroxysteroid dehydrogenase; androgen receptor; cholesterol monooxygenase (side chain cleaving); di isononylphthalate; phthalic acid; steroidogenic acute regulatory protein; unclassified drug; adrenal cell; adrenal gland; animal cell; animal experiment; animal tissue; article; cell ultrastructure; controlled study; down regulation; embryo development; environmental exposure; nonhuman; nucleotide sequence; prenatal exposure; protein expression; sex differentiation; structure analysis; testis cell; 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex Hormones; Adrenal Glands; Androgen Antagonists; Animals; Cholesterol Side-Chain Cleavage Enzyme; Dichlorodiphenyl Dichloroethylene; Dose-Response Relationship, Drug; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Gestational Age; Gonadal Steroid Hormones; Maternal Exposure; Phosphoproteins; Phthalic Acids; Pregnancy; Rats, Sprague-Dawley; Receptors, Androgen; RNA, Messenger |
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