Di(isononyl) phthalate (DINP) and di(isodecyl) phthalate (DIDP) are not mutagenic
McKee, RH; Przygoda, RT; Chirdon, MA; Engelhardt, G; Stanley, M
HERO ID
680077
Reference Type
Journal Article
Year
2000
Language
English
PMID
| HERO ID | 680077 |
|---|---|
| In Press | No |
| Year | 2000 |
| Title | Di(isononyl) phthalate (DINP) and di(isodecyl) phthalate (DIDP) are not mutagenic |
| Authors | McKee, RH; Przygoda, RT; Chirdon, MA; Engelhardt, G; Stanley, M |
| Journal | Journal of Applied Toxicology |
| Volume | 20 |
| Issue | 6 |
| Page Numbers | 491-497 |
| Abstract | Recently there have been reports of liver and kidney tumors in rodents following long-term exposure to di(isononyl) phthalate (DINP). Mechanistic studies suggested that the liver tumors were a consequence of peroxisomal proliferation, whereas the kidney tumors (found only in male rats) were associated with induction of alpha(2u)-globulin. Because both peroxisomal proliferation and alpha(2u)-globulin are considered to be non-genotoxic carcinogenic processes, it seemed appropriate to investigate the genotoxic potential of DINP. Additional studies were also conducted on di(isodecyl) phthalate (DIDP), a structurally related substance that also induces peroxisomal proliferation, although it has not been tested in a carcinogenicity bioassay. The DINP was tested in Salmonella, in vitro cytogenetics and mouse micronucleus assays, whereas DIDP was evaluated in a mouse micronucleus test. All of these tests produced negative results, i.e. neither phthalate was mutagenic in any of the test systems. These data are consistent with results of other published and unpublished genotoxicity tests and provide support for the hypothesis that the liver and kidney tumors induced by DINP were the result of non-genotoxic processes. |
| Doi | 10.1002/1099-1263(200011/12)20:6<491::AID-JAT724>3.0.CO;2-H |
| Pmid | 11180272 |
| Wosid | WOS:000166090100011 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Animals; CHO Cells; Chromosome Aberrations; Cricetinae; Mice; Mutagenicity Tests; Phthalic Acids/ toxicity; Rats; Rats, Sprague-Dawley; Salmonella |
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