Hydrolysis of phthalate esters by purified rat and human carboxylesterases
Mentlein, R; Butte, W
HERO ID
680352
Reference Type
Journal Article
Year
1989
Language
English
PMID
| HERO ID | 680352 |
|---|---|
| In Press | No |
| Year | 1989 |
| Title | Hydrolysis of phthalate esters by purified rat and human carboxylesterases |
| Authors | Mentlein, R; Butte, W |
| Journal | Biochemical Pharmacology |
| Volume | 38 |
| Issue | 18 |
| Page Numbers | 3126-3128 |
| Abstract | Because of their wide use as plasticizers and production in millions of tons per year, phthalate esters have become environmental pollutants. Phthalates or metabolites of them are suspected to be hepatocarcinogenic [1,2] and teratogenic [3] after chronic exposure and/or high dosage. Their metabolism in rats and humans involves the hydrolysis of one ester bond. and further metabolites are formed from the monoesters [1, 4]. Hydrolytic activity has been detected in rat pancreas, liver, mucosa, kidney and lung [5], but apart from the characterization of a pancreatic hpase [6] the identification of mammalian esterases or lipases involved in the metabolism of phthalate esters is unsatisfactory so far. Since in mammals hepatic carboxylesterases are mainly responsible [7,8] for the hydrolysis of many ester- or amide-type drugs, we determined the action of purified carboxylesterases from rat and human liver on various phthalate diesters, in order to evaluate the contribution of these detoxication enzymes on the metabolism of these xenobiotics. |
| Doi | 10.1016/0006-2952(89)90027-0 |
| Pmid | 2783169 |
| Url | http://www.sciencedirect.com/science/article/pii/0006295289900270 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Biochem. Pharmacol. 38: 3126-3128. |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>DCN-186389</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Plasticizers</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Phthalates</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Liver enzymes</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Metabolic study</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Enzyme activity</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Detoxifying agents</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Detoxification</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>In vitro studies</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Laboratory animals</kw> |
| Is Peer Review | Yes |
| Is Qa | No |
| Relationship(s) |
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