Epstein-Barr virus-transformed human lymphoblastoid cells for study of sister chromatid exchange and their evaluation as a test system
Tohda, H; Khoraguchi,; Alkte,
HERO ID
688981
Reference Type
Journal Article
Year
1980
Language
English
PMID
| HERO ID | 688981 |
|---|---|
| In Press | No |
| Year | 1980 |
| Title | Epstein-Barr virus-transformed human lymphoblastoid cells for study of sister chromatid exchange and their evaluation as a test system |
| Authors | Tohda, H; Khoraguchi,; Alkte, |
| Journal | Cancer Research |
| Volume | 40 |
| Issue | 12 |
| Page Numbers | 4775-4780 |
| Abstract | Epstein-Barr virus-transformed human lymphoblastoid cell lines are suitable for detection of sister chromatid exchange (SCE) induced by mutagens-carcinogens because they have shown a stable chromosome number and stable frequency of spontaneous SCE for more than two years in culture. Their spontaneous and induced SCE frequencies were practically the same as those of phytohemagglutinin-stimulated lymphocytes from the same blood donors. The SCE responses of one established cell line, NL3, to 13 typical mutagens and five nonmutagens were examined. This cell line responded to all the mutagens tested but not to the nonmutagens. The SCE-inducing activities of these chemicals were well correlated with their mutagenic activities assayed with the Salmonella system by Ames' and Sugimura's groups, although there were a few but significant deviations. |
| Pmid | 6254652 |
| Is Certified Translation | No |
| Dupe Override | 688981 |
| Comments | Journal: CANCER RES 40 ISSN: |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |