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Phthalates: Metabolism and exposure
Wittassek, M; Angerer, J
HERO ID
698241
Reference Type
Journal Article
Subtype
Review
Year
2008
Language
English
PMID
| HERO ID | 698241 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2008 |
| Title | Phthalates: Metabolism and exposure |
| Authors | Wittassek, M; Angerer, J |
| Journal | International Journal of Andrology |
| Volume | 31 |
| Issue | 2 |
| Page Numbers | 131-138 |
| Abstract | In human metabolism studies we found that after oral application of di(2-ethylhexyl) phthalate (DEHP), diisononyl phthalate (DiNP) and di(2-propylheptyl) phthalate (DPHP), at least 74, 44 and 34%, respectively, are excreted via urine. In contrast to the short chain phthalates, their oxidized products, not the simple monoesters, were found to be the main metabolites. Based on urinary phthalate metabolite concentrations we estimated in 102 German subjects between 6 and 80 years of age median daily intakes (microg/kg/day) of 2.7 for DEHP, 2.1 for di-n-butyl phthalate, 1.5 for diisobutyl phthalate, 0.6 for DiNP, and 0.3 for butylbenzyl phthalate. In general, children have higher exposures compared to adults and seem to have a more effective oxidative metabolism of phthalates. For individual phthalates tolerable daily intake (TDI) values have been deduced. However, in rats some phthalates have been shown to act as endocrine disrupters via a common mechanism of action in a dose-additive manner. Therefore, the concept of a cumulative TDI value may be more appropriate for the consideration of the overall exposure and the potential human health risks resulting from everyday and simultaneous exposure to several phthalates. |
| Doi | 10.1111/j.1365-2605.2007.00837.x |
| Pmid | 18070048 |
| Wosid | WOS:000253710200012 |
| Url | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2605.2007.00837.x/pdf |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Copenhagen, DENMARK |
| Conference Name | 4th Copenhagen Workshop on Endocrine Disrupters |
| Comments | Source: Web of Science WOS:000253710200012 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Administration, Oral; Child; Environmental Exposure; Humans; Phthalic Acids/administration & dosage/blood/ pharmacokinetics/urine |
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