Long-term exposure to traffic-related air pollution and the risk of coronary heart disease hospitalization and mortality
Gan, W; Koehoorn, M; Davies, H; Demers, P; Tamburic, L; Brauer, M
HERO ID
699145
Reference Type
Journal Article
Year
2011
Language
English
PMID
| HERO ID | 699145 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | Long-term exposure to traffic-related air pollution and the risk of coronary heart disease hospitalization and mortality |
| Authors | Gan, W; Koehoorn, M; Davies, H; Demers, P; Tamburic, L; Brauer, M |
| Journal | Environmental Health Perspectives |
| Volume | 119 |
| Issue | 4 |
| Page Numbers | 501-507 |
| Abstract | BACKGROUND: Epidemiologic studies have demonstrated that exposure to road traffic is associated with adverse cardiovascular outcomes. OBJECTIVES: To identify specific traffic-related air pollutants that are associated with the risk of coronary heart disease (CHD) morbidity and mortality to support evidence-based environmental policy making. METHODS: This population-based cohort study included a 5-year exposure period and a 4-year follow-up period. All residents aged 45-85 years who resided in Metropolitan Vancouver during the exposure period and without known CHD at baseline were included in this study (n = 452,735). Individual exposures to traffic-related air pollutants including black carbon, fine particles (aerodynamic diameter ≤2.5 µm; PM2.5), NO2, and NO were estimated at subjects' residences using land use regression models and integrating changes in residences during the exposure period. CHD hospitalizations and deaths during the follow-up period were identified from provincial hospitalization and death registration records. RESULTS: An interquartile range elevation in the average concentration of black carbon (0.94×10-5/m filter absorbance, equivalent to approximately 0.75 µg/m3 elemental carbon) was associated with a 3% increase in CHD hospitalization (95% confidence interval, 1-5%) and a 6% increase in CHD mortality (3-9%) after adjustment for age, sex, preexisting comorbidity, neighborhood socioeconomic status, and co-pollutants (PM2.5 and NO2). There were clear linear exposure-response relationships between black carbon and coronary events. CONCLUSIONS: Long-term exposure to traffic-related fine particulate air pollution, indicated by black carbon, may partly explain the observed associations between exposure to road traffic and adverse cardiovascular outcomes. |
| Doi | 10.1289/ehp.1002511 |
| Pmid | 21081301 |
| Wosid | WOS:000289065900031 |
| Url | http://content.ebscohost.com/ContentServer.asp?T=P&P=AN&K=60711185&S=R&D=8gh&EbscoContent=dGJyMNHr7ESeqLQ4xNvgOLCmr0qep7FSsK24TbaWxWXS&ContentCustomer=dGJyMOzpr0yzrrNLuePfgeyx44Hy7fEA |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | air pollution;cohort studies;coronary heart disease;particulate matter;vehicle emissions;DIESEL-EXHAUST INHALATION;FINE PARTICULATE MATTER;ST-SEGMENT DEPRESSION;LAND-USE REGRESSION;CARDIOVASCULAR-DISEASE;MYOCARDIAL-INFARCTION;CARDIOPULMONARY MORTALITY;ELDERLY SUBJECTS;ARTERY-DISEASE;ASSOCIATION;ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH |
| Is Qa | No |